Serometrix is leveraging its SimPep™ platform to develop an internally funded pipeline of novel lead compounds. These lead compounds are focused on unmet commercial opportunities in oncology, autoimmune, inflammation, and infectious disease.

Serometrix has a growing pre-clinical therapeutic pipeline which consists exclusively of internal discoveries enabled by the SimPep™ platform.

The unique capability provided by SimPep™ yields powerful clinically predictive models, which are advancing the understanding of important biological phenomena and enabling the further discovery of a great number of potential therapeutic lead compounds.

 

Predictive Product Pipeline

 
 

GIP-C34 is a novel oncology therapeutic lead compound that works on the principle of cell cycle control. This peptide utilizes a unique natural mechanism of action related to S-phase arrest (US Patents 5,674,842 and 5,707,963).

CRPC-L09 is a set of compounds that have demonstrated in vitro ability to down regulate the AR pathway, having potential as a therapeutic for Castration Resistant Prostate Cancer.

MET2-L14 is a novel oncology therapeutic lead compound that has been discovered to have strong anti-metastatic properties. This compound has demonstrated in vitro regulatory activity for dissociation, migration, cell adhesion, invasion and proliferation (US and International Patents Pending).

RDS1-L12 is a novel DNA Repair Inhibitor discovered to enhance the effectiveness of radiation therapy in a non-toxic manner. This compound is designed to dramatically reduce the frequency and dose of radiation therapy through a unique mechanism of action which gently disables cellular DNA repair mechanisms without interfering with p53 pathways.

LDL4-L10 is a novel set of compounds discovered that have proven in vitro to antagonize the interaction between PCSK9 and LDLR for the treatment of hypercholesterolemia.

AD-L06 is a novel set of compounds under development for the prevention of inflammatory response in the brain believe by the company to be at the heart of Alzheimer's Disease.

RVI-L08 is a novel retroviral integrase inhibitor that safely prohibits the multimerization of the highly conserved integrase enzyme used by many human retroviruses including HIV. This multimerization process is critical to the integration of viral genetic material with the DNA of the infected host cell.